Down's syndrome in infants of diabetic mothers

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High incidence of Down's syndrome in infants of diabetic mothers.

The incidence of Down's syndrome was studied in 1870 infants of diabetic mothers out of 22,300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for diabetes and all cases of Down's syndrome were confirmed by chromosome analysis. Down's syndrome (all trisomy 21) was diagnosed in 35 infants: seven were born to mothers with gestational diabetes an...

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Infants of diabetic mothers.

9 Grodsky, G. M., and Forsham, P. H.: An immunochemical assay of total extractable insulin in man. J. Clin. Invest. 39:1070, i960. 10 Field, J. B., and Woodson, M. L.: Studies on the circulating insulin inhibitor found in some diabetic patients exhibiting chronic insulin resistance. J. Clin. Invest. 38:551, 1959. 11 Mitchell, M. L.: Interaction of radioinsulin with serum proteins in vitro and w...

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Infants of diabetic mothers.

Advances in the management of the mother with diabetes have reduced the rate of morbidity and mortality for her infant. Aggressive control of maternal glycemic status is warranted, because most morbidities are epidemiologically and pathophysiologically closely linked to fetal hyperglycemia and hyperinsulinemia. The burgeoning public health problem of overweight and obesity in children will like...

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Infants of diabetic mothers.

Infants of diabetic mothers (IDMs) can present with various symptoms and disorders. The neonatal nurse must be able to assess the infant for glucose control and other anomalies.

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Infants of diabetic mothers.

1024 These infants are remarkable not only because, like foetal versions of Shadrach, Meshach and Abednego, they emerge at least alive from within the fiery metabolic furnace of diabetes mellitus, but because they resemble one another so closely that they might well be related. They are plump, sleek, liberally coated with vemix caseosa, fullfaced and plethoric. The umbilical cord and tile place...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1998

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.79.2.198d